Although the active site of ASV integrase does not undergo significant conformational changes on binding the required metal cofactor, that of HIV-1 does.
Zinc is an essential cofactor for the important antioxidant enzyme Superoxide Dismutase.
Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus.
It tells you a bit about the catalytic activity of the enzyme and its cofactor Pyridoxal Phosphate.
From the value of A we may separate those members which contain a particular element a ik as a factor, and write the portion aik A ik; A k, the cofactor of ar k, is called a minor of order n - i of the determinant.